Okay, simple solution is to use the Python GUI to send an API call to a Blynk virtual pin - the same one that your Blynk on/off button is attached to.
You then have the code in your sketch that will turn the LED on and off according to the state of the virtual pin, as described here:
The API documentation is here:
I’d recommend using the GET method for everything.
However, if you’re building a serious IoT home automation system then I’d suggest a different approach, which is to use Node-Red and MQTT plus the Blynk plugin for Node-Red.
Pete.