No, it’s basically the same, and some things, such as WiFi connection are actually easier than an Uno plus ESP-01.
The ESP32 has an onboard 5v to 3.3v regulator, to allow it to be powered via USB.
The pins use 3.3v logic levels, but are 5v tolerant, and most sensors etc are 3.3-5v tolerant too.
If you do have an6 issues then you can use a logic level shifter, but i’ve only ever had one situation where I’ve had to do that.
This topic is about ESP8266 boards, but many of the points raised relate to ESP32s too…
As far as Ethernet boards not working consistently with Blynk, I think it’s more a case of Ethernet boards not working consistently - full stop!
Pete.